Endocrine Abstracts

Background: Various genetic and environmental factors are appear to contribute to the development of kidney disease in type 2 diabetes. Small ubiquitin-related modifier 4 (SUMO4) appear to play a role in development and/or progression of diabetic nephropathy. Substitution of methionine with valine at codon 55 (M55V) of SUMO4 enhances activity of nuclear factor-kB, a central mediator of inflammation proapoptotic events.Aims: To investigate the association...